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Free, publicly-accessible full text available May 19, 2026
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Ghosh, Pratyusha; Buhaichuk, Nataliia; Carr, Jenna; Tani, Sakurako; Hazra, Raj Shankar; Mathew, Sijo; Choi, Yongki; Quadir, Mohiuddin (, Journal of Materials Chemistry B)A synthetic biomolecular condensate (sBC) was developed using zein, a hydrophobic protein derived from plants. These particles can be used as an artifiical platform to understand the structure and function of natural protein-rich condensates.more » « less
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Edvall, Connor; Kale, Narendra; Tani, Sakurako; Ambhore, Shubhashri; Hossain, Rayat; Ozoude, Chukwuebuka; Van_Horsen, Karl; Mohammad, Jiyan; Tuvin, Daniel M; Kalathingal, Santo; et al (, ACS Applied Bio Materials)Free, publicly-accessible full text available April 21, 2026
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You, Seungyong; Tani, Sakurako; Mallik, Sanku; Yang, Zhongyu; Quadir, Mohiuddin; Choi, Yongki (, Catalysis Science & Technology)Understanding how substrate structure alters an enzyme's conformational landscape is central to catalyst design. Using single-molecule electronic sensors, we reveal how substitutions on an HDAC8 substrate modulate the enzyme's underlying catalytic dynamics. We demonstrate that a trifluoroacetyl group accelerates catalysis, while a Boc cap and an allosteric activator synergistically simplify the kinetic pathway by stabilizing productive conformations. These findings provide direct, real-time insight into how substrate-induced conformational dynamics control enzyme catalysis.more » « lessFree, publicly-accessible full text available December 9, 2026
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Thomas, Salim A; Alharthi, Naif S; Petersen, Reed J; Aldrees, Ahmed; Tani, Sakurako; Anderson, Kenneth J; Granlie, Joseph; Pringle, Todd A; Payne, Scott A; Choi, Yongki; et al (, ACS Nano)
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